Clinical and mycological benefits of topical application of honey, olive oil and beeswax in diaper dermatitis

  • N.S. Al-Waili
    Correspondence
    Corresponding author and reprint requests: N. S. Al-Waili, New Technologies, Inc., and Life Support Technologies, Inc., The Mount Vernon Hospital, 7th Avenue 12 North, Mount Vernon, NY 10550, USA
    Affiliations
    Dubai Specialized Medical Center, Islamic Establishment for Education, Dubai, United Arab Emirates
    Search for articles by this author

      ABSTRACT

      Twelve infants suffering from diaper dermatitis were treated four times daily for 7 days with a mixture containing honey, olive oil and beeswax. The severity of erythema was evaluated on a five-point scale. Three infants had severe erythema and ulceration, four had moderate erythema, and five had moderate erythema with maceration. The initial mean lesion score of 2.91 ± 0.79 declined significantly (p < 0.05) to 2.0 ± 0.98 (day 3), 1.25 ± 0.96 (day 5) and 0.66 ± 0.98 (day 7). Candida albicans was isolated initially from four patients, but from only two patients after treatment. This topical treatment was safe and well-tolerated, and demonstrated clinical and mycological benefits in the treatment of diaper dermatitis.

      Keywords

      References

        • Hurwitz S
        Clinical pediatric dermatology. 1st edn. Saunders, Philadelphia1981: 27-30
        • Jodan W
        • Lawson K
        • Berg R
        • Franxman J
        • Marrer A
        Diaper dermatitis: frequency and severity among a general infant population.
        Pediatr Dermatol. 1986; 3: 198-207
        • Atherton J
        The aetiology and management of irritant diaper dermatitis.
        J Eur Acad Dermatol Venerol. 2001; 15: 1-4
        • Ferrazzini G
        • Kaiser R
        • Hirsig Chen K
        • Wehrli M
        Microbiological aspects of diaper dermatitis.
        Dermatology. 2003; 206: 136-141
        • Hoppe E
        Treatment of orophyaryngeal candidiasis and candidal diaper dermatitis in neonates and infants: review and reappraisal.
        Pediatr Infect Dis J. 1997; 16: 885-894
        • Tuck K
        • Hayball P
        Major phenolic compounds in olive oil.
        J Nutr Biochem. 2002; 13: 636-644
        • Noa M
        • Mas R
        Effect of D-002 on the pre-ulcerative phase of carrageenan-induced colonic ulceration in the guinea pig.
        J Pharm Pharmacol. 1998; 50: 549-553
        • Al-Waili N
        • Saloom K
        Effects of topical honey on post-operative wound infections due to gram positive and gram negative bacteria following caesarean sections and hysterectomies.
        Eur J Med Res. 1999; 26: 126-130
        • Al-Waili N
        Investigating the antimicrobial activity of natural honey and its effects on the pathogenic bacterial infections of surgical wounds and conjunctiva.
        J Med Food. 2004; 7: 210-222
        • Al-Waili N
        Therapeutic and prophylactic effects of crude honey on chronic seborrheic dermatitis and dandruff.
        Eur J Med Res. 2001; 6: 306-308
        • Tranter S
        • Tassou C
        • Nychas J
        The effect of the olive phenolic compound, oleuropein, on growth and enterotoxin B production by Staphylococcus aureus.
        J Appl Bacteriol. 1993; 74: 253-259
        • Al-Waili N
        Topical application of natural honey, beeswax and olive oil mixture to treat patients with atopic dermatitis or psoriasis: partially controlled study.
        Complement Ther Med. 2003; 11 (222): 226
        • Al-Waili N
        Safety and efficacy of topical application of honey, olive oil and beeswax mixture in patients with tinea versicolor, tinea cruris, tinea corporis and tinea faciei. Pilot study.
        Complement Ther Med. 2004; 12: 45-47
        • Molan P
        The role of honey in the management of wounds.
        J Wound Care. 1999; 8: 415-418
        • Al-Waili N
        • Boni N
        Effects of honey ingestion on nitric oxide in saliva.
        FASEB J. 2003; 17: 235
        • Al-Waili N
        Identification of nitric oxide metabolites in various honeys and effects of honey on plasma and urinary nitrite/nitrate concentration.
        J Med Food. 2003; 6: 350-357
        • Al-Waili N
        Honey lowers plasma prostaglandin concentrations in normal individuals.
        J Med Food. 2003; 6: 129-133
        • Visioli F
        • Bellosta S
        • Galli C
        Oleuropein. The bitter principle of olives enhances nitric oxide production by mouse macrophages.
        Life Sci. 1998; 62: 541-546
        • Al-Waili N
        Identification of nitric oxide in sweat and tear.
        FASEB J. 2003; 17: 342
        • Akh U
        • Zefirov L
        The physiological role of nitric oxide.
        Usp Fiziol Nauk. 1999; 30: 54-72