If you don't remember your password, you can reset it by entering your email address and clicking the Reset Password button. You will then receive an email that contains a secure link for resetting your password
If the address matches a valid account an email will be sent to __email__ with instructions for resetting your password
Instituto de Biomedicina de Sevilla (IBiS), SpainDepartment of Medicine, Universidad de Sevilla, SpainHospital Universitario Virgen del Rocío, Seville, Spain
† The first and last author contributed equally to this work. †† Members of the COVID-19@Spain Study Group who have made substantial data collection contributions are listed in the Appendix.
To analyse the characteristics and predictors of death in hospitalized patients with coronavirus disease 2019 (COVID-19) in Spain.
Methods
A retrospective observational study was performed of the first consecutive patients hospitalized with COVID-19 confirmed by real-time PCR assay in 127 Spanish centres until 17 March 2020. The follow-up censoring date was 17 April 2020. We collected demographic, clinical, laboratory, treatment and complications data. The primary endpoint was all-cause mortality. Univariable and multivariable Cox regression analyses were performed to identify factors associated with death.
Results
Of the 4035 patients, male subjects accounted for 2433 (61.0%) of 3987, the median age was 70 years and 2539 (73.8%) of 3439 had one or more comorbidity. The most common symptoms were a history of fever, cough, malaise and dyspnoea. During hospitalization, 1255 (31.5%) of 3979 patients developed acute respiratory distress syndrome, 736 (18.5%) of 3988 were admitted to intensive care units and 619 (15.5%) of 3992 underwent mechanical ventilation. Virus- or host-targeted medications included lopinavir/ritonavir (2820/4005, 70.4%), hydroxychloroquine (2618/3995, 65.5%), interferon beta (1153/3950, 29.2%), corticosteroids (1109/3965, 28.0%) and tocilizumab (373/3951, 9.4%). Overall, 1131 (28%) of 4035 patients died. Mortality increased with age (85.6% occurring in older than 65 years). Seventeen factors were independently associated with an increased hazard of death, the strongest among them including advanced age, liver cirrhosis, low age-adjusted oxygen saturation, higher concentrations of C-reactive protein and lower estimated glomerular filtration rate.
Conclusions
Our findings provide comprehensive information about characteristics and complications of severe COVID-19, and may help clinicians identify patients at a higher risk of death.
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated coronavirus disease 2019 (COVID-19) emerged in China in December 2019 and has spread globally, creating a worldwide pandemic and a public health crisis of historic dimensions [
]. The clinical spectrum of COVID-19 varies widely, from asymptomatic disease to pneumonia and life-threatening complications, including acute respiratory distress syndrome (ARDS), multisystem organ failure and ultimately death [
Several case series or cohorts describing the clinical characteristics and outcomes of patients with severe COVID-19 have been reported summarizing the experience of city or regional hospitals in China [
Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
]. However, variations in the rates for COVID-19 hospitalizations and deaths may occur across different areas even in the same country, suggesting differences in population characteristics or inequities in the access to care [
Clinical characteristics and outcomes of hospitalised patients with COVID-19 treated in Hubei (epicenter) and outside Hubei (non-epicenter): a nationwide analysis of China.
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.
]. None of these three cohorts explored both clinical and laboratory variables associated with hospital death.
Our study aimed to determine the epidemiologic and clinical characteristics of hospitalized patients with COVID-19 in Spain, and to identify clinical and laboratory predictors of death.
Patients and methods
Design and patient selection
COVID-19@Spain is a retrospective nationwide cohort study of patients admitted to Spanish hospitals with laboratory-confirmed COVID-19 infection by real-time PCR (RT-PCR) assay for SARS-CoV-2. Investigators from participating centres were asked to include the first consecutive hospitalized patients (up to 100) meeting the study criteria from the start of the epidemic in Spain until 17 March 2020. The Ethics Committee for Research with Medicines of Hospital General Universitario Gregorio Marañón approved the study and waived informed consent for the collection of clinical data.
Investigations
The data source comprised the electronic medical records. All data were collected using an electronic case report form (eCRF), a modified version of the World Health Organization International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) Core CRF [
International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC). COVID-19 Core Case Report Form. Acute Respiratory Infection Clinical Characterisation Data Tool.
] and was hosted at SEIMC (Spanish Society of Infectious Diseases and Clinical Microbiology)/GESIDA (AIDS Study Group) Foundation (FSG).
The variables registered included administrative data, epidemiologic information and type of clinical specimen in which the diagnosis was confirmed. We also registered demographics, comorbidities, current medications, signs and symptoms at admission, baseline laboratory tests results, chest radiographic findings at baseline and during follow-up, development of ARDS and other complications during hospitalization, use of medications with purported activity against COVID-19, use of adjunctive medications to modulate the host inflammatory response, admission to a high-dependency unit or ICU, noninvasive ventilation, mechanical ventilation, use of extracorporeal membrane oxygenation, vasopressor agents and renal replacement therapy.
The clinical status of the patients as of 17 April 2020 was categorized as discharged alive (with date of discharge), alive and currently hospitalized or dead (with date of death). For patients who were discharged and subsequently readmitted during the study period, only one hospital admission episode was considered for purposes of analysis.
Outcome
The primary endpoint was all-cause mortality. Baseline was the date of hospital admission. The follow-up censoring date was 17 April 2020.
Definitions
Comorbidities and complications during hospitalization were defined as diagnoses included in the medical record. Cancer was defined as the presence of an active solid or haematologic malignant neoplasm. Obesity was defined as a body mass index of >30 kg/m2. ARDS was defined as the acute onset or worsening of respiratory symptoms with severe hypoxaemia and bilateral opacities on chest radiograph not fully explained by cardiac failure or fluid overload [
The investigators of each participating centre vouch for the completeness and accuracy of the data. FSG monitors maintained close contact with investigators for problem resolution during the period of data retrieval; they checked the database for missing, invalid and inconsistent data; and they managed queries before the analysis.
Statistical analysis
Univariable and multivariable Cox regression analyses were performed to identify factors associated with death. To obtain a reduced set of variables from the broad set of predictors, we carried out a blockwise forward procedure allocating the predictor variables into five clusters: sociodemographic characteristics, comorbidities, admission signs and symptoms, vital signs and laboratory parameters. A multivariable regression analysis was fitted within each block using two criteria to achieve the best set of predictors: relevance to the clinical situation and statistical significance (p < 0.10). We used variance inflation factors to detect collinearity among predictors included in the multivariable models. We carried out a sensitivity analysis in which the order of entry of the blocks was inverted. We checked the proportional hazards assumption. Variables with more than 25% missing values have not been considered, and missing values were treated as a separate category for analysis. Heterogeneity introduced by different hospitals was accounted for by using robust methods to estimate standard errors, and thus to calculate 95% confidence intervals and p values.
Statistical analyses were performed by Stata 15.0 software (StataCorp, College Station, TX, USA). This study was registered with ClinicalTrials.gov as trial NCT04355871. The STROBE guidelines were used to ensure the reporting of the study (Supplementary Table S1).
Results
The final cohort included 4035 hospitalized patients (Supplementary Fig. S1) in whom SARS-CoV-2 was detected by RT-PCR by testing nasopharyngeal swabs (89.6%), pharyngeal swabs (13.4%), low respiratory tract specimens (1.3%) and other specimens (4.4%). The median admission date was 13 March 2020, with little variability among the median admission date between the centres (range from 6 to 17 March). The median follow-up time was 34 days (interquartile range (IQR), 24–37 days). A total of 141 patients (3.6%) were discharged and readmitted during the study period, a median time of 5 days (IQR, 2–9 days) after discharge.
Demographics and presenting clinical features
Patient characteristics, categorized by survival, are shown in Table 1. In brief, male subjects accounted for 61.0%, the median age was 70 years and 25.1% were ≥80 years old. Most patients were Spanish-born whites. The age distribution of patients stratified by sex is shown in Fig. 1(A).
Table 1Demographics, comorbidity data and current medications of 4035 hospitalized patients with COVID-19 stratified according to vital status at study censoring date
Fig. 1(A) Distribution of hospitalized patients with coronavirus disease 2019 (COVID-19) stratified by age and sex. (B) Mortality of patients with COVID-19 stratified by age and sex.
At least one comorbidity was present in 73.8%, and 26.7% had at least three comorbid conditions. The most common comorbidities were arterial hypertension (51.2%), chronic heart disease (23.3%), diabetes mellitus (21.8%), chronic pulmonary disease (not asthma) (17.9%) and obesity (13.8%). Only 0.7% patients had HIV. Before admission, 19.4% patients had been provided angiotensin-converting enzyme (ACE) inhibitors and 17.3% were receiving angiotensin II receptor blockers (Table 1).
The median duration of symptoms before hospitalization was 4 days (IQR, 2–7 days), and the most commonly reported symptoms were history of fever (81.0%), cough (71.8%), malaise (64.0%), dyspnoea (49.1%), upper respiratory tract symptoms (30.8%), myalgia or arthralgia (24.9%) and sputum production (24.1%) (Supplementary Table S2). Abnormal vital signs at admission included fever (40.9%), arterial hypotension (18.8%) and marked tachypnoea (10.9%). Low age-adjusted arterial oxygen saturation (SaO2) levels on room air were reported in 26.6% patients (Supplementary Table S3).
Chest radiograph findings
Infiltrates on initial chest radiograph were observed in 77.6% patients, of whom 71.3% had bilateral involvement. Over the whole hospital course, worsening of the baseline infiltrates was observed in 64.7% patients, with new lesions in 51.0%.
Laboratory findings
Baseline laboratory findings are shown in Table 2. The most common abnormalities in blood counts included lymphopenia (54.2%) and thrombocytopenia (31.5%). The median neutrophil-to-lymphocyte ratio was 4.5. A prolonged activated partial thromboplastin time was present in 9.4%, and 57.1% had D-dimer levels above the normal range. High serum levels were reported from alanine aminotransferase (25.3%), aspartate aminotransferase (34.7%), lactate dehydrogenase (64.5%), creatine kinase (23.5%), C-reactive protein (91.9%) and procalcitonin (14.2%). Low serum albumin was found in 36.0% patients, and 6.8% had an estimated glomerular filtration rate of <30 mL/min/1.73 m2 by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Ferritin and interleukin 6 were determined in a limited number of patients, and high concentrations of these parameters were found in 75.1% and 90.0% respectively.
Table 2Laboratory findings of 4035 hospitalized patients with COVID-19 stratified according to vital status at study censoring date
Laboratory parameter
Alive (n = 2904)
Death (n = 1131)
p
Total (N = 4035)
Haemoglobin
No. of patients with data
2860
1120
3980
Median (IQR) (g/L)
13.8 (12.6–14.9)
12.9 (11.5–14.4)
<0.001
13.6 (12.3–14.8)
Haematocrit
No. of patients with data
2832
1105
3937
Median (IQR) (%)
41.0 (37.9–44.0)
39.1 (34.8–43.0)
<0.001
40.6 (37.0–44.0)
WBC count
Median (IQR) (×109/L)
5635 (4330–7420)
6900 (5000–9470)
<0.001
5910 (4490–7990)
Distribution
<0.001
>12 000 × 109/L
152/2854 (5.3)
160/1117 (14.3)
312/3971 (7.9)
<4000 × 109/L
529/2854 (18.5)
137/1117 (12.3)
666/3971 (16.8)
Neutrophil count
Median (IQR) (/μL)
3920 (2800–5560)
5300 (3530–7700)
<0.001
4200 (2920–6120)
<1000/μL
51/2848 (1.8)
24/1113 (2.2)
0.448
75/3961 (1.9)
Lymphocyte count
Median (IQR) (/μL)
1000 (700–1360)
780 (540–1160)
<0.001
900 (640–1300)
<1000/μL
1423/2852 (49.9)
727/1111 (65.4)
<0.001
2150/3963 (54.2)
Neutrophil-to-lymphocyte ratio
Median (IQR)
3.9 (2.5–6.5)
6.6 (3.7–11.4)
<0.001
4.5 (2.7–7.7)
Distribution
Tertile 1
1094/2839 (38.5)
222/1106 (20.1)
<0.001
1316/3945 (33.4)
Tertile 2
1005/2839 (35.4)
309/1106 (27.9)
1314/3945 (33.3)
Tertile 3
740/2839 (26.1)
575/1106 (52.0)
1315/3945 (33.3)
Platelets
Median (IQR) (×109/L)
181 000 (143 000–229 000)
168 000 (130 000–221 000)
<0.001
178 000 (139 000–226 000)
Platelets <150 000 × 109/L
831/2842 (29.2)
416/1118 (37.2)
<0.001
1247/3960 (31.5)
Prolonged APTT (>39.2 seconds or ratio >1.25)
161/2232 (7.2)
133/880 (15.1)
<0.001
294/3112 (9.4)
INR
Median (IQR)
1.1 (1.0–1.2)
1.2 (1.1–1.3)
<0.001
1.1 (1.0–1.2)
INR > 1.1
954/2376 (40.1)
549/925 (59.3)
<0.001
1503/3301 (45.5)
D-dimer
Median (IQR) (ng/mL)
548 (328–934)
740 (410–1590)
<0.001
580 (339–1040)
High D-dimer levels (>500 ng/mL)
639/1184 (54.0)
253/379 (66.7)
<0.001
892/1563 (57.1)
Glucose
No. of patients with data
2766
1084
3850
Median (IQR) (mg/dL)
106 (93–126)
125 (104–165)
<0.001
110 (95–136)
Creatinine
No. of patients with data
2832
1111
3943
Median (IQR)
0.88 (0.72–1.07)
1.10 (0.84–1.46)
<0.001
0.92 (0.74–1.18)
eGFR (mL/min/1.73 m2) (CKD-EPI)
Median (IQR)
84.1 (65.3–97.4)
60.2 (40.1–80.4)
<0.001
78.4 (56.5–93.6)
Distribution
<0.001
>60 mL/min/1.73 m2
2234/2797 (79.9)
552/1098 (50.3)
2786/3895 (71.5)
30–59 mL/min/1.73 m2
456/2797 (16.3)
388/1098 (35.3)
844/3895 (21.7)
<30 mL/min/1.73 m2
107/2797 (3.8)
158/1098 (14.4)
265/3895 (6.8)
Sodium
No. of patients with data
2825
1109
3934
Median (IQR) (mEq/L)
138 (135–140)
137 (135–140)
0.008
138 (135–140)
Potassium
No. of patients with data
2770
1070
3840
Median (IQR) (mEq/L)
4.1 (3.8–4.4)
4.2 (3.8–4.6)
<0.001
4.1 (3.8–4.4)
ALT
Median (IQR) (U/L)
27 (18–42)
25 (17–38)
0.003
26 (18–41)
High serum levels ≥40 U/L and ≤200 U/L
630/2369 (26.6)
190/870 (21.8)
0.021
820/3239 (25.3)
High serum levels >200 U/L
23/2369 (1.0)
8/870 (0.9)
31/3239 (1.0)
AST
Median (IQR) (U/L)
31 (23–45)
34 (23–52)
0.033
32 (23–48)
High serum levels ≥ 40 U/L and ≤200 U/L
680/2051 (33.1)
291/750 (38.8)
0.011
971/2801 (34.7)
High serum levels >200 U/L
17/2051 (0.8)
9/750 (1.2)
26/2801 (0.9)
AST/ALT ratio
<0.001
<1
675/2013 (33.5)
166/733 (22.6)
841/2746 (30.6)
≥1
1338/2013 (66.5)
567/733 (77.4)
1905/2746 (69.4)
Total bilirubin
No. of patients with data
1920
730
2650
Median (IQR) (mg/dL)
0.50 (0.37–0.71)
0.56 (0.39–0.87)
<0.001
0.50 (0.37–0.80)
Serum albumin
Median (IQR) (g/dL)
3.6 (3.2–4.0)
3.4 (3.0–3.8)
<0.001
3.5 (3.2–3.9)
Low albumin levels (<3.4 g/dL)
310/991 (31.3)
198/420 (47.1)
<0.001
508/1411 (36.0)
Lactate dehydrogenase
Median (IQR) (U/L)
281 (215–382)
318 (250–463)
<0.001
290 (224–403)
High lactate dehydrogenase (>250 U/L)
1154/1895 (60.9)
510/683 (74.7)
<0.001
1664/2578 (64.5)
CRP
Median (IQR) (mg/L)
44 (16–95)
87 (38–168)
<0.001
54 (20–116)
High CRP levels (>5 mg/L)
2388/2654 (90.0)
990/1023 (96.8)
<0.001
3378/3677 (91.9)
Procalcitonin
Median (IQR) (μg/L)
0.09 (0.05–0.16)
0.22 (0.10–0.56)
<0.001
0.11 (0.06–0.25)
High procalcitonin levels (>0.50 μg/L)
105/1135 (9.2)
119/439 (27.1)
<0.001
224/1574 (14.2)
Creatine kinase
Median (IQR) (U/L)
90 (56–169)
101 (56–217)
0.048
92 (56–182)
High creatine kinase levels (>190 U/L)
184/882 (20.9)
102/336 (30.4)
<0.001
286/1218 (23.5)
Ferritin
Median (IQR) (μg/L)
611 (278–1238)
792 (400–1670)
0.002
649 (301–1363)
High ferritin levels (>300 μg/L)
315/433 (72.7)
125/153 (81.7)
0.028
440/586 (75.1)
Interleukin 6
Median (IQR) (pg/mL)
33 (13–77)
117 (40–512)
42 (16–105)
High interleukin levels (>4.3 pg/mL)
175/201 (87.1)
58/58 (100.0)
0.004
233/259 (90.0)
Values are displayed as n/N with data (%) unless otherwise indicated.
High-dependency unit or ICU admission was required for 18.5% patients, 15.5% underwent mechanical ventilation, 11.9% received vasopressors and 3.0% received renal-replacement therapy (Supplementary Table S4). Virus-targeted agents were administered to 82.0% patients: lopinavir/ritonavir to 70.4%, hydroxychloroquine to 65.5% and subcutaneous interferon beta to 29.2%, usually in combination with lopinavir/ritonavir. Host-targeted agents included systemic corticosteroids in 28.0% and tocilizumab in 9.4%. Antibiotics other than azithromycin were administered to 80.9% and antifungals to 3.2% (Supplementary Table S5).
Complications and mortality
The full list of complications during the hospital course is provided in Supplementary Table S6. The most common were ARDS (31.5%), acute kidney injury (15.4%), presumed bacterial pneumonia (10.6%), heart failure (5.8%) and bloodstream infection (4.9%). During the study period, 28.0% patients died, 64.1% were discharged and 7.8% remained hospitalized. The median (IQR) time to death since the beginning of symptoms and since hospital admission was 13 (9–19) days and 10 (6–16) days, respectively. Death was particularly high among patients aged ≥80 years (54.9%) (Fig. 1(B)) and those with three or more comorbid conditions (47.7%). Death was also very high among those with ARDS (59.3%), those who were admitted to the ICU (42.4%) and those who underwent mechanical ventilation (45.7%). The median (IQR) length of stay was 4 (1–9) days for patients who were discharged and 35 (32–38) days for those who remained hospitalized at the censoring date.
Predictors of death
Independent predictors of death in the different clusters of variables are shown in Table 3. In the final adjusted analysis, we found 17 factors independently associated with an increased hazard of death: male sex, older age, arterial hypertension, obesity, liver cirrhosis, chronic neurologic disorder, active cancer, dementia, dyspnoea, confusion, low age-adjusted SaO2 on room air, higher white cell blood count, higher neutrophil-to-lymphocyte ratio, lower platelet count, prolonged international normalized ratio, lower estimated glomerular filtration rate and higher concentrations of C-reactive protein (Fig. 2). No collinearity was detected, the proportional hazards assumption was fulfilled and the results were not changed when the order of entry of the blocks was inverted. Kaplan-Meier plots for death according to age and sex are shown in Fig. 3. The adjusted hazard ratio of death for being admitted early in the epidemic (before 13 March) versus later was 1.07 (95% confidence interval, 0.90–1.28; p 0.407). The variable unilateral or bilateral lung opacities had missing values in 29% individuals and was not included in the final model. However, when this variable was included in the model, the adjusted hazard ratio of death for bilateral opacities compared to unilateral opacities was 1.32 (95% confidence interval, 0.11–1.55; p 0.002). We also carried out two post hoc analyses (data not shown). In the first one, the predictors of mortality among patients aged ≤65 years were not substantially different from those found in the whole dataset. In the second analysis, the mortality hazard did not change depending on the seroprevalence of IgG anti–SARS-CoV-2 at the provincial level, according to a recent nationwide study in Spain [
Our cohort describes the presenting characteristics and outcomes of 4035 patients with COVID-19 admitted to 127 centres in Spain during the first month of the country outbreak. We are aware of three prior published nationwide cohorts of hospitalized patients with COVID-19, two from China [
Clinical characteristics and outcomes of hospitalised patients with COVID-19 treated in Hubei (epicenter) and outside Hubei (non-epicenter): a nationwide analysis of China.
] and one from the United Kingdom. The majority of patients in all four cohorts were male. However, compared to Chinese patients, those from Spain and the United Kingdom were, on average, two decades older and had a prevalence three times higher of comorbid conditions. It is thus not surprising that mortality was substantially higher in Spain (28%) and the United Kingdom (26%) than in China (1.4% and 3.2%). Presenting features were similar in all cohorts. However, dyspnoea was less frequent in Chinese patients, suggesting a more severe course in the older Spanish and British patients. In our cohort, age was the main determinant of death, as has been in other series of hospitalized patients with COVID-19 [
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.
Independent of the higher prevalence of comorbidities, it cannot be ruled out that older patients could not have been prioritized to receive ICU treatment. Death was also significantly higher in men than in women, as has also been described in other cohorts [
Clinical characteristics and outcomes of hospitalised patients with COVID-19 treated in Hubei (epicenter) and outside Hubei (non-epicenter): a nationwide analysis of China.
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.
]. There are sex differences in innate and adaptive immune responses that might have an impact on the inflammatory response and outcomes of COVID-19 and therefore deserve further investigation [
]. Hypertension was not only the most common comorbidity in our cohort, as in other studies, but it was an independent predictor of mortality. The association between hypertension and poor outcomes in COVID-19 does not seem to be simply a matter of high prevalence; alternative explanations include preexisting hypertensive end-organ or endothelial damage, and interactions between COVID-19 and antihypertensive medications [
]. Many patients with hypertension were receiving ACE inhibitors or angiotensin II receptor blockers, but these drugs did not increase mortality. Obesity was the fifth most common comorbidity in our cohort, but one with the highest hazard of mortality. Obesity has been found to increase the risk of hospitalization and severe outcomes during influenza seasons [
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.
Clinical characteristics and outcomes of COVID-19 among patients with pre-existing liver disease in United States: a multi-center research network study.
Clinical characteristics and outcomes of COVID-19 among patients with pre-existing liver disease in United States: a multi-center research network study.
]. We identified several routine laboratory markers as predictors of mortality, including the neutrophil-to-lymphocyte ratio, an indicator of systemic inflammation that has been found to be of prognostic utility in sepsis [
Our study is limited by the retrospective design and the high number of sites, which might have jeopardized the quality of the data. We tried to solve this by selecting simple and well-defined variables and by carefully monitoring of the data. Admission criteria might have differed between the sites; nevertheless, we controlled the site effect in the analysis. We could not include in the multivariable model some potentially interesting laboratory parameters; nor could we include changes in laboratory findings over time. The study's strengths include the large sample size, which allowed the identification of a high number of predictors of death at admission, the analysis of clinical and laboratory variables, and the inclusion of sites from areas with different incidence rates.
In summary, here we report the clinical characteristics of a large cohort of patients with COVID-19 consecutively admitted to hospitals in Spain during the first month of the epidemic. Our findings provide comprehensive information about the characteristics and complications of severe COVID-19, and may help us identify patients at hospital admission with a higher risk of death.
Transparency declaration
This work was supported by Fundación SEIMC/GeSIDA . JB, JR-B, IJ, JC, JP and JRA received funding for research from Plan Nacional de I+D+i 2013-2016 and Instituto de Salud Carlos III , Subdirección General de Redes y Centros de Investigación Cooperativa , Ministerio de Ciencia, Innovación y Universidades , cofinanced by European Development Regional Fund ‘A way to achieve Europe’, Operative Program Intelligent Growth 2014–2020, Spanish AIDS Research Network (RIS) (RD16/0025/0017 (JB), RD16/0025/0018 (JRA), RD16CIII/0002/0006 (IJ)) and Spanish Network for Research in Infectious Diseases (REIPI) (RD16/0016/0001 (JRB), RD16/0016/0005 (JC) and RD16/0016/0009 (JP).
JB reports grants and personal fees from AbbVie, grants and personal fees from Gilead, grants and personal fees from MSD, grants and personal fees from ViiV Healthcare and personal fees from Janssen, outside the submitted work. PR reports personal fees from AbbVie, grants and personal fees from Gilead, personal fees from Janssen, grants from MSD and personal fees from ViiV Healthcare, outside the submitted work. IJ reports personal fees from Gilead and ViiV Healthcare, outside the submitted work. JRA reports grants and personal fees from Alexa, grants and personal fees from Gilead, grants and personal fees from MSD, grants and personal fees from Janssen, grants and personal fees from Serono, grants and personal fees from Teva and grants and personal fees from ViiV Healthcare, outside the submitted work. The other authors report no conflicts of interest relevant to this article.
Appendix.
The COVID-19@Spain Study Group
Fundación SEIMC-GESIDA: Aznar Muñoz, Esther; Gil Divasson, Pedro; González Muñiz, Patricia; Muñoz Aguirre, Clara. Hospital General Universitario Gregorio Marañón: López, Juan Carlos; Ramírez-Schacke, Margarita; Gutiérrez, Isabel; Tejerina, Francisco; Aldámiz-Echevarría, Teresa; Díez, Cristina; Fanciulli, Chiara; Pérez-Latorre, Leire; Parras, Francisco; Catalán, Pilar; García-Leoni, María E.; Pérez-Tamayo, Isabel; Puente, Luis; Cedeño, Jamil; Berenguer, Juan. Hospital Universitario La Paz:Díaz Menéndez, Marta; de la Calle Prieto, Fernando; Arsuaga Vicente, Marta; Trigo Esteban, Elena; Lago Núñez, Mª del Mar; de Miguel Buckley, Rosa; Cadiñaños Loidi, Julen; Busca Arenzana, Carmen; Mican, Alfredo; Mora Rillo, Marta; Ramos Ramos, Juan Carlos; Loeches Yagüe, Belén; Bernardino de la Serna, José Ignacio; García Rodríguez, Julio; Arribas López, José Ramón. Hospital Infanta Leonor: Such Diaz, Ana; Álvaro Alonso, Elena; Izquierdo García, Elsa; Torres Macho, Juan; Cuevas Tascon, Guillermo; Troya García, Jesús; Mestre Gómez, Beatriz; Jiménez González de Buitrago, Eva; Fernández Jiménez, Inés; Tebar Martínez, Ana Josefa; Brañas Baztán, Fátima; Valencia de la Rosa, Jorge; Pérez Butragueño, Mario; Alvarado Blasco, Marta; Ryan, Pablo. Complejo Hospitalario Virgen de la Salud: Sepúlveda Berrocal, Mª Antonia; Yera Bergua, Carmen; Toledano Sierra, Pilar; Cano Llorente, Verónica; Zafar Iqubal-Mirza, Sadaf; Muñiz, Gema; Martín Pérez, Inmaculada; Mozas Moriñigo, Helena; Alguacil, Ana; García Butenegro, María Paz. Hospital Universitario Rafael Méndez: Peláez Ballesta, Ana Isabel; Morcillo Rodríguez, Elena. Hospital Universitario de Cruces: Goikoetxea Agirre, Josune; Blanco Vidal, María José; Nieto Arana, Javier; del Álamo Martínez de Lagos, Mikel. Hospital de Melilla: Pérez Hernández, Isabel A.; Pérez Zapata, Inés. Hospital San Eloy de Barakaldo: Silvariño Fernández, Rafael; Ugalde Espiñeira, Jon. Hospital Universitario Central de Asturias: Asensi Álvarez, Víctor; Suárez Pérez, Lucia; Suárez Diaz, Silvia; Yllera Gutiérrez, Carmen. Hospital General Universitario de Alicante: Boix, Vicente; Díez Martínez, Marcos; Carreres Candela, Melissa. Hospital Virgen de la Victoria: Gómez-Ayerbe, Cristina; Sánchez-Lora, Javier; Velasco Garrido, José Luis; López-Jódar, María; Santos González, Jesús. Hospital Universitario Puerto Real: Ruiz Aragón, Jesús; Virto Peña, Ianire. EOXI Pontevedra e Salnés: Alende Castro, Vanessa; Brea Aparicio, Ruth. Hospital de Figueres: Vega Molpeceres, Sonia; Pons Viñas, Estel. Hospital Sant Jaume de Calella: del Río Pérez, Oscar; Valero Rovira, Silvia. Hospital del Mar: Villar-García, Judit; Gómez-Junyent, Joan; Knobel, Hernando; Cánepa, María Cecilia; Castañeda Espinosa, Silvia; Sorli Redò, Luisa; Güerri-Fernández, Roberto; Milagro Montero, María; Horcajada, Juan Pablo. Hospital Virgen de la Arrixaca: García Vázquez, Elisa; Moral Escudero, Encarnación; Hernández Torres, Alicia. Hospital de Can Misses: García Almodóvar, Esther. Hospital de Sagunto: Sáez Barberá, Carmen; Karroud, Zineb. Hospital Clínico San Cecilio: Hernández Quero, José; Vinuesa García, David; García Fogeda, José Luis; Peregrina, José Antonio. Hospital Universitario Príncipe de Asturias: Novella Mena, María; Hernández Gutiérrez, Cristina; Sanz Moreno, José; Pérez Tanoira, Ramón; Sierra Rodríguez, Rodrigo; Alonso Menchén, David; Gutiérrez García, Aida; Arranz Caso, Alberto; Cuadros González, Juan; Álvarez de Mon Soto, Melchor. Parc Sanitari Sant Joan de Déu: Díaz de Brito Fernández, Vicente Ferrer; Sanmarti Vilamala, Montserrat; Gabarrell Pascuet, Aina; Molina Morant, Daniel; España Cueto, Sergio; Cámara Fernández, Jonathan; Sabater Gil, Albert; Muñoz López, Laura. Hospital Nuestra Señora de Gracia: Sáez Escolano, Paula; Bejarano Tello, Esperanza. HC Marbella Internacional Hospital: Sempere Alcocer, Marco Antonio; Álvarez Martin, Salvador. Hospital La Princesa: De los Santos Gil, Ignacio; García-Fraile, Lucio; Sampedro Núñez, Miguel; Barrios Blandino, Ana; Rodríguez Franco, Carlos; Useros Brañas, Daniel; Villa Martí, Almudena; Oliver Ortega, Javier; Costanza Espiño Álvarez, Alexia; Sanz Sanz, Jesús. Hospital Josep Trueta: Rexach Fumaña, María; Abascal Cambras, Ivette; Pérez Jaén, Ana del Cielo. Hospital Dos de Maig: Sala Jofre, Clara; Casas Rodríguez, Susana. Hospital Arnau de Vilanova-Lliria: Tortajada Alamilla, Cecilia; Oltra, Carmina. Hospital General Universitario de Elche: Masiá Canuto, Mar; Gutiérrez Rodero, Félix. Hospital Clínico Universitario de Valencia: Ferrer Ribera, Ana; Bea Serrano, Carlos. Complejo Asistencial de Ávila: Pedromingo Kus, Miguel; Garcinuño, María Ángeles; Fiorante, Silvana; Pérez Pinto, Sergio. Hospital Comarcal de Alcañiz: Hernández Machín, Pilar; Alastrué Violeta, Alba. Hospital Universitario Marqués de Valdecilla: Fariñas Álvarez, María Carmen; González Rico, Claudia; Arnaiz de las Revillas, Francisco; Calvo, Jorge; Gozalo, Mónica. Hospital Quiron-Salud de Torrevieja: Mora Gómez, Francisco. Hospital Universitario Miguel Servet: Milagro Beamonte, Ana; Latorre-Millán, Miriam; Rezusta López, Antonio; Martínez Sapiña, Ana. SCIAS, Hospital de Barcelona: Meije, Yolanda; Duarte Borges, Alejandra; Pareja Coca, Julia; Clemente Presas, Mercedes. Fundación Hospital Universitario Alcorcón: Losa García, Juan Emilio; Vegas Serrano, Ana. Hospital Álvaro Cunqueiro: Pérez-Rodríguez, M. Teresa; Pérez González, Alexandre. Complejo Asistencial Universitario de Salamanca: Belhassen-García, Moncef; Rodríguez-Alonso, Beatriz; López-Bernus, Amparo; Carbonell, Cristina. Hospital Universitario Severo Ochoa: Torres Perea, Rafael; Cantón de Seoane, Juan; Alonso, Blanca; Kamal, Sara Lidia; Cajuela, Lucia; Roa, David; Cervero, Miguel; Oreja, Alberto; Avilés, Juan Pablo; Martín, Lidia. Hospital CIMA-Sanitas: Pelegrín Senent, Iván; Rouco Esteves Marques, Rosana. Hospital HLA Inmaculada: Parra Ruiz, Jorge; Ramos Sesma, Violeta. Hospital Universitario Rio Hortega: Abadia Otero, Jessica. Hospital de Guadalajara: Salillas Hernando, Juan; Torres Sánchez del Arco, Robert; Torralba González de Suso, Miguel; Serrano Martínez, Alberto; Gilaberte Reyzábal, Sergio; Pacheco Martínez-Atienza, Marina; Liébana Gómez, Mónica; Fernández Rodríguez, Sara; Varela Plaza, Álvaro; Calvo Sánchez, Henar. Hospital Universitario Infanta Sofía: Martínez Martín, Patricia; González- Ruano, Patricia; Malmierca Corral, Eduardo; Rábago Lorite, Isabel; Pérez-Monte Mínguez, Beatriz. Hospital Comarcal de Blanes: García Flores, Ángeles; Comas Casanova, Pere. Hospital Universitari de Tarragona Joan XXIII: Sirisi, Merce; Rojas, Richard. Hospital Universitario Basurto: Díaz de Tuesta del Arco, José Luis; Figueroa Cerón, Ruth; González Sarria, Ander. Hospital Universitario de Canarias: Alemán Valls, Remedios; Alonso Socas, María del Mar. Hospital Universitario de Gran Canaria Dr Negrín: Sanz Peláez, Oscar; Mohamed Ramírez, Karim. Hospital Son Espases: Riera Jaume, Melchor; Vilchez, Helem Haydee; Albertí, Francesc; Cañabate, Ana Isabel. Hospital Universitario de Móstoles: Moreno Cuerda, Víctor J.; Álvarez Kaelis, Silvia; Álvarez Zapatero, Beatriz; García García, Alejandro; Isaba Ares, Elena; Morcate Fernández, Covadonga; Pérez Rodríguez, Andrea. Complejo Hospitalario Universitario A Coruña: Ramos Merino, Lucía; Castelo Corral, Laura; Rodríguez Mahía, María; González Bardanca, Mónica; Sánchez Vidal, Efrén; Míguez Rey, Enrique. Hospital Costa del Sol: De la Torre Lima, Javier; García de Lomas Guerrero, José Mª. Hospital Clínico Universitario Lozano Blesa: Morte, Elena; Loscos, Silvia; Camón, Ana. Hospital Mutua de Terrassa: Gómez García, Lucía; Boix Palop, Lucia; Dietl Gómez-Luengo, Beatriz. Hospital de la Plana: Pedrola Gorrea, Iris; Blasco Claramunt, Amparo. Hospital Virgen de la Concha–Complejo Asistencial de Zamora: López Mestanza, Cristina; Fraile Villarejo, Esther. Complejo Hospitalario Universitario Insular Materno-Infantil: Tosco Núñez, Tomás; Aroca Ferri, María. Hospital de la Marina Baixa: Algado Rabasa, José Tomas; Garijo Saiz, Ana María; Amador Prous, Concepción. Hospital Universitario Virgen Macarena: Baño, Jesús Rodriguez; Retamar, Pilar; Valiente, Adoración; López-Cortés, Luis E.; Sojo, Jesús; Gutiérrez-Gutiérrez, Belén; Bravo-Ferrer, José; Salamanca, Elena; Palacios, Zaira R.; Pérez-Palacios, Patricia; Peral, Enrique; Pérez de León, José Antonio; Sánchez-Gómez, Jesús; Marín-Barrera, Lucía; García-Jiménez, Domingo. Hospital Universitari de Bellvitge: Carratalà, Jordi; Abelenda-Alonso, Gabriela; Ardanuy, Carmen; Bergas, Alba; Cuervo, Guillermo; Domínguez, María Ángeles; Fernández-Huerta, Miguel; Gudiol, Carlota; Lorenzo-Esteller, Laia; Niubó, Jordi; Pérez-Recio, Sandra; Podzamczer, Daniel; Pujol, Miquel; Rombauts, Alexander; Trullen, Núria. Hospital Universitario y Politécnico la Fe: Salavert Lletí, Miguel; Castro Hernández, Iván. Hospital Universitario del Vinalopó: Hernández Belmonte, Adriana; Martínez Goñi, Raquel. Hospital de Sabadell (Parc Tauli): Navarro Vilasaró, Marta; Calzado Isbert, Sonia; Cervantes García, Manuel; Gomila Grange, Aina; Gasch Blasi, Oriol; Machado Sicilia, María Luisa; Van den Eynde Otero, Eva; Falgueras López, Luis; Navarro Sáez, María del Carmen. Hospital Clinic de Barcelona: Martínez, Esteban; Marcos, Mª Ángeles; Mosquera, Mar; Blanco, José Luis; Laguno, Montserrat; Rojas, Jhon; González-Cordón, Ana; Inciarte, Alexy; Torres, Berta; De la Mora, Lorena; Soriano, Alex. Hospital Universitario de la Ribera: Martínez Macias, Olalla; Pérez Doñate, Virginia. Fundación Jiménez Díaz: Cabello Úbeda, Alfonso; Carrasco Antón, Nerea; Álvarez Álvarez, Beatriz; Petkova Saiz, Elizabet; Górgolas Hernández-Mora, Miguel; Prieto Pérez, Laura; Carrillo Acosta, Irene; Heili Frades, Sara; Villar Álvarez, Felipe; Fernández Roblas, Ricardo; Milicua Muñoz, José María. Hospital Clínico Universitario de Valladolid: Fernández Espinilla, Virginia; Dueñas Gutiérrez, Carlos Jesús; Hernán García, Cristina. Hospital Clínico San Carlos: González-Romo, Fernando; Merino Amador, Paloma; Rueda López, Alba; Martínez Jordán, Jorge; Medrano Pardo, Sara; Díaz de la Torre, Irene; Posada Franco, Yolanda; Delgado-Iribarren, Alberto. Hospital Santa Creu i Sant Pau: López-Contreras González, Joaquín; Pascual Alonso, Pablo; Pomar Solchaga, Virginia; Rabella García, Nuria; Benito Hernández, Natividad; Domingo Pedrol, Pere; Bonfill Cosp, Xavier; Padrós Selma, Rafael; Puig Campmany, Mireia; Mancebo Cortés, Jordi; Gurguí Ferrer, Mercè. Clínica Universitaria de Navarra–Campus Madrid: Íñigo Pestaña, Melania; Pérez García, Alejandra. Hospital Son Llatzer: Sorní Moreno, Patricia; Izko Gartzia, Nora. Hospital General de la Defensa Gómez Ulla: Membrillo de Novales, Francisco Javier; Simón Sacristán, María; Zamora Cintas, Maribel; Martínez Martínez, Yolanda; Fernández-González, Pablo; Alcántara Nicolás, Francisco; Aguirre Vila-Cora, Alejandro; López Tizón, Elena; Ramírez-Olivencia, Germán; Estébanez Muñoz, Miriam. Hospital Universitario de Álava: Sáez de Adana Arróniz, Ester; Portu Zapirain, Joseba; Gainzarain Arana, Juan Carlos; Ortiz de Zárate Ibarra, Zuriñe; Moran Rodríguez, Miguel Ángel; Canut Blasco, Andrés; Hernáez Crespo, Silvia; Balerdi Sarasola, Leire; Morales García, Cristina; Corral Saracho, Miguel; Valcarce González, Zeltia. Hospital Santos Reyes: Arenal Andrés, Noelia; Rodríguez Tarazona, Raquel Elisa. Hospital Dr José Molina Orosa: Iglesias Llorente, Laura; Loureiro Rodríguez, Beatriz. Hospital Vall d’Hebrón: Sánchez Montalvá, Adrián; Espinosa Pereiro, Juan; Almirante, Benito; Miarons, Marta; Sellarés, Júlia; Larrosa, María; García, Sonia; Marzo, Blanca; Villamarín, Miguel; Fernández, Nuria. Hospital Universitario Rey Juan Carlos: Pérez-Jorge Peremarch, Conchita; Resino Foz, Elena; Espigares Correa, Andrea; Álvarez de Espejo Montiel, Teresa; Navas Clemente, Iván; Quijano Contreras, María Isabel; Nieto Fernández del Campo, Luis Alberto; Jiménez Álvarez, Guillermo. Complejo Hospitalario Universitario Santa Lucía: Guillamón Sánchez, Mercedes; García García, Josefina. Hospital Santa Bárbara: Muñoz Hornero, Constanza. Complejo Hospitalario Universitario de Ferrol: Mariño Callejo, Ana; Valcarce Pardeiro, Nieves. Hospital de l'Esperit Sant: Smithson Amat, Alex; Chico Chumillas, Cristina. Hospital Universitario los Arcos del Mar Menor: Sánchez Serrano, Adriana; García Villalba, Eva Pilar. Hospital HLA Universitario Moncloa: Jiménez Martínez, Isabel; Estrada Fernández, Guillermo; Lorén Vargas, María; Parra Arribas, Nuria; Martínez Cilleros, Carmen; Villasante de la Puente, Aránzazu; García Delange, Teresa; Ruiz Rodríguez, María José; Robledo del Prado, Marta; Abad Almendro, Juan Carlos. Hospital Virgen del Puerto: Muñoz del Rey, José Román; Jiménez Álvaro, Montaña. Hospital Marina Salud de Dénia: Coy Coy, Javier; Poquet Catala, Inmaculada. Hospital Universitario de Jerez: Santos Peña, Marta; Naranjo Velasco, Virginia. Hospital Reina Sofía de Tudela: Manso Gómez, Tamara; Quilez Ágreda, Delia. Hospital Clínico Universitario de Santiago de Compostela: Barbeito Castiñeiras, Gema; Domínguez Santalla, María Jesús. Hospital Universitario del Henares: Mao Martín Laura; Alonso Navarro, Rodrigo; Ampuero Martinich, Jose David; Barrós González, Raquel; Galindo Martín, María Aránzazu; Herrera Pacheco, Lourdes; Martínez Avilés, Rocío; Rodrigo González, Sara; Rodríguez Leal, Cristóbal Manuel. Hospital Universitario Lucus Augusti: Romay Lema, Eva María; Suárez Gil, Roi. Hospital de Donostia: Ibarguren Pinilla, Maialen; Marimón Ortiz de Zárate, José María; Vidaur Tello, Loreto; Kortajarena Urkola, Xabier. Hospital de Urduliz Alfredo Espinosa: García Gómez, Miriam; Aranguren Arostegui, Asier. Hospital de Mendaro: Álvarez de Castro, Maria; Martínez Mateu, Cintia María. Hospital Juan Ramón Jiménez: Rodríguez Gómez, Francisco; Muñoz Beamud, Francisco. Hospital de Tortosa Virgen de la Cinta: Chamarro Martí, Elena; Cardona Rivera, Merce. Hospital Riotinto: Zakariya-Yousef Breval, Ismail; Rico Rodríguez, Marta. Hospital Vega Baja: Llenas García, Jara; Sánchez Arenas, Mª Carmen. Hospital Puerta de Hierro: Fernández Cruz, Ana; Calderón Parra, Jorge; López Dosil, Marcos; Ramos Martínez, Antonio; Múñez Rubio, Elena; Callejas Díaz, Alejandro; Vázquez Comendador, José Manuel; Diego Yagüe, Itziar; Expósito Palomo, Esther; Anel Pedroche, Jorge. Hospital Universitario de Getafe: Álvarez Franco, Raquel ; Fernández de Orueta, Lucía; Vates Gómez, Roberto; Cardona Arias, Andrés Felipe; Marguenda Contreras, Pablo; Gaspar Alonso-Vega, Gabriel; Aranda Rife, Elena María; Martínez Cifre, Blanca; Roger Zapata, Daniel; Martín Rubio, Irene. Hospital General de la Palma: Barbosa Ventura, André; Piñero, Iván. Hospital El Bierzo: Bahamonde Carrasco, Alberto; Runza Buznego, Paula. Fundación Hospital de Calahorra: Talavera García, Eva; Lamata Subero, Marta. Hospital Alto Deba: Urrutia Losada, Ainhoa; Arteche Eguizabal, Lorea. Hospital Universitario San Juan de Alicante: Delgado Sánchez, Elisabet; Molina Peinado, Virginia. Hospital de Guadarrama: Caro Bragado, Sarah; Domínguez de Pablos, Gema. Hospital Universitario de Jaén: Roldán Fontana, Carolina; Herrero Rodríguez, Carmen. Hospital de Mataró: Force Sanmartín, Luis; Aranega, Raquel. Hospital de Palamós: Mera Fidalgo, Arantzazu; Toda Savall, María Roca. Hospital Universitario de Valme: Merchante Gutiérrez, Nicolas ; León Jiménez, Eva María. Clínica Universitaria de Navarra–Campus Navarra: Del Pozo León, José Luís. Hospital Clínica Benidorm: Serralta Buades, Josefa; Cabrera Tejada, Ginger Giorgiana. Hospital Doce de Octubre: Fernández-Ruiz, Mario; Aguado, José María; Maestro de la Calle, Guillermo. Hospital Universitario Virgen del Rocío: Cisneros, José Miguel; Pachón, Jerónimo; Aguilar-Guisado, Manuela; Aldabó, Teresa; Avilés, María Dolores; Bueno, Claudio; Cordero-Matía, Elisa; Escoresca, Ana; Gálvez-Benítez, Lydia; Infante, Carmen; Martín, Guillermo; Praena, Julia; Roca, Cristina; Salamanca, Celia; Suárez-Benjumea, Alejandro. Hospital Universitario Ramón y Cajal: Vizcarra, Pilar; Quereda, Carmen; Rodriguez Dominguez, Mario José; Gioia, Francesca; Norman, Francesca; Del Campo, Santos; Cantón Moreno, Rafael. Hospital Universitario San Pedro: Oteo Revuelta José, Antonio; Santibáñez Sáenz, Paula; Cervera Acedo, Cristina; Ruiz Martínez, Carlos; Blanco Ramos, José R.; Azcona Gutiérrez, José M.; García García, Concepción; Alba Fernández, Jorge; Ibarra Cucalón, Valvanera; San Franco, Mercedes; Metola Sacristán, Luis. Hospital Quirón A Coruña: Meijide Míguez, Héctor; Paulos Viñas, Silvia. HM Sanchinarro: Menéndez, Justo; Villares Fernández, Paula; Montes Andújar, Lara. Hospital Francesc de Borja: Navarro Batet, Álvaro; Ferrer Santolaria, Anna. Complejo Hospitalario Universitario Nuestra Señora de La Candelaria: Padilla Salazar, María de la Luz; Abella Vázquez, Lucy; Hayek Peraza, Marcelino; García Pardo, Antonio; Hernández Carballo, Carolina. Hospital Universitario HM Montepríncipe: Ruiz Fernández, Andrés Javier; Barrio López, Isabel. Hospital Universitario HM Puerta del Sur: Martakoush Alí. Hospital Universitario HM Torrelodones: Rojas-Vieyra, Agustín. Hospital Universitario HM Madrid: García Calvo, Sonia; Villarreal García-Lomas, Mercedes. Hospital Don Benito-Villanueva de la Serena: Vizcaíno Callejón, Marta; García García, María Pilar. Hospital de Viladecans: Lérida Urteaga, Ana; Carrasco Fons, Natalia; María Sanjuan, Beatriz; Martín González, Lydia; Sanz Zamudio, Camilo. Centro Nacional de Epidemiología: Jarrín, Inmaculada; Alejos, Belén; Moreno, Cristina; Rava, Marta; Iniesta, Carlos; Izquierdo, Rebeca; Suárez-García, Inés; Díaz, Asunción; Ruiz-Alguero, Marta; Hernando, Victoria.
Appendix A. Supplementary data
The following are the Supplementary data to this article:
Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Clinical characteristics and outcomes of hospitalised patients with COVID-19 treated in Hubei (epicenter) and outside Hubei (non-epicenter): a nationwide analysis of China.
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.
International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC). COVID-19 Core Case Report Form. Acute Respiratory Infection Clinical Characterisation Data Tool.
Clinical characteristics and outcomes of COVID-19 among patients with pre-existing liver disease in United States: a multi-center research network study.
30431-6&id=fx1.jpg){kind=link}
30431-6&id=gr1.jpg){kind=link}
30431-6&id=gr2.jpg){kind=link}
30431-6&id=gr3.jpg){kind=link}